This manual will reveal to you all the secrets of permanent fat loss. It is written by a man
who has discovered these secrets the hard way - through long years of trial and error.
Using the information in this manual will allow you master the art and science of losing
body fat by a shorter and less costly route; by “modeling” those who have gone before
you and learning from an expert.
The primary goals of this manual are to help you lose fat permanently without drugs,
supplements or gimmicks and to educate you in the process of losing fat. In other words,
my goal is to turn you into a “fat loss expert”… to teach you the reasons why and help
you to understand the process…and to do so without bias or ulterior motive.
To achieve this goal, I decided - after careful consideration - to self publish and to write
this book in layman’s terms, with a minimum of scientific jargon and without long lists of
scientific references. Instead of long, boring scientific discussions of biochemistry – and
instead of long lists of references to scientific papers - you will find sprinkled throughout
the manual, brief mention of interesting studies and quotes that are important and relevant
to a point being made.
This book was written for you as a simple, yet detailed instruction manual. You get stepby-
step instructions: Do this, don’t do that, eat this, don’t eat that, and so on.
This is not just an informational book – it is a complete system that will take you from
where you are now to where you want to be – in the shortest possible period of time.
There are dozens of outstanding books on the subjects of nutrition and fat loss, but far too
many of them are mired down in technical details and scientific terminology that are
either too difficult to understand or simply too damn boring. Many of these books leave
you with more questions than answers. You begin reading confused and when you finish
reading, you’re even more confused.
Others encode their writing into a cryptic jargon that can only be deciphered by fellow
scientists and academicians. Sometimes I think bodybuilding, fitness and nutrition writers
are more concerned with trying to impress and to receive the approval of their academic
peers than to help their readers achieve their goals.
It never ceases to amaze me how some of these writers can take a simple concept and
make it sound mystical, complex, and a thousand times more confusing than it really is.

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The third volume of the Annals of Traditional Chinese Medicine carries
the theme of Cancer Treatment. Since the commencement of this book
series, the Editorial Board has emphasized its main objective, that is to
help modernize Chinese medicine, thus providing a convenient platform
for all scientists, including those who belong to the traditional camp as
well as members of the modern scientific community who insist on strict
deductive approaches.
Cancer is obviously one of the most common areas where demand
for alternative treatment is overwhelming. A significant portion of the
American and European populations regularly consumes health
supplements to either prevent cancer or as adjuvant therapy during
cancer treatment. Health surveys conducted in Hong Kong (a city of
predominantly Chinese people) have shown that over 90% of cancer
patients consume products of Chinese medicine, either prescribed by
Chinese medicine practitioners or purchased over-the-counter. Choosing
Cancer as the theme of our third volume is therefore appropriate. There
is no intention of guiding the reader on the choice of therapy, nor is there
any suggestion of preferences of the available options of treatment
(although a few solid examples are given). Instead we want to introduce
the justification and logic of using Chinese medicine as an adjunct, discuss
about the basic principles and the options that are available, expose the
regional and cultural varieties, and some problems related to their use,
describe some natural products of particular interests and lastly, give
examples of specific cancers being treated with herbal therapy.
Using modern scientific concepts to understand and explain traditional
or alternative medicine is logical and unavoidable. Indeed, the Annals
has already adopted this principle. Nevertheless, we welcome distinguished
scholars of the very traditional stream to explain their views, particularly
at this time, in the popular field of cancer.
Professor Dai-Han Zhou is a learned scholar in Chinese medicine
who has written extensively on the principles and practice of Chinese
medicine for cancer patients. Readers will find his articles quite outof-
the-norm as he stresses on holistic care and the importance of
individualized therapy. On the other hand, Prof. Zhou tries to equate
herbalists’ observations as evidence-based medicine, and assumes that
some herbs work via specific channels resembling those being targeted
by new therapies like Iressa, Tarceva and Avastin. Professor Zhou quoted
one clinical trial using a proprietor herbal medicine. In that situation, he
accepts generalization and ignores individualization. The article is really
interesting because it exposes the complexity of thoughts of the modern
day Chinese medicine expert. While the discrepancies observed may be
controversial, Prof. Zhou’s strong criticisms against over-treatment in
modern medicine and his call for higher rates of survival among cancer
patients should be established as good advice for all.
Professor Zhou’s orthodox account is well balanced with Professor
Stephen Sagar’s Western medicine perspectives on the scientific basis of
cancer care in Chinese medicine.
This volume attempts to give very rich accounts of the varieties of
cancer treatment available, as well as the cultural differences in China,
Hong Kong, Japan, India, Italy, the United Kingdom and the United
States. There are altogether seven chapters sharing this load.
Since herbal medicine can be the main basis for the maintenance of
survival in spite of the persistence of cancer or cancer metastases, natural
products and phytochemistry that contribute toward survival via various
channels should be explored. This volume provides a number of high
quality articles (by authors from Canada, India and the US) on the subject.
Lastly, there are some real examples of integrated treatment for specific
cancers that will be of interest to readers. Two good examples from
China are chosen.
With the growing demand for complementary and alternative medicine
from the global public and a parallel interest from the service providers,
we believe that this volume will provide valuable information in the area
of cancer for all.

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Substance use and dependence cause a significant burden to individuals and
societies throughout the world. The World Health Report 2002 indicated that
8.9% of the total burden of disease comes from the use of psychoactive
substances. The report showed that tobacco accounted for 4.1%, alcohol 4%,
and illicit drugs 0.8% of the burden of disease in 2000. Much of the burden
attributable to substance use and dependence is the result of a wide variety
of health and social problems, including HIV/AIDS, which is driven in many
countries by injecting drug use.
This neuroscience report is the first attempt by WHO to provide a
comprehensive overview of the biological factors related to substance use
and dependence by summarizing the vast amount of knowledge gained in
the last 20-30 years. The report highlights the current state of knowledge of
the mechanisms of action of different types of psychoactive substances, and
explains how the use of these substances can lead to the development of
dependence syndrome.
Though the focus is on brain mechanisms, the report nevertheless
addresses the social and environmental factors which influence substance
use and dependence. It also deals with neuroscience aspects of interventions
and, in particular, the ethical implications of new biological intervention
strategies.
The various health and social problems associated with use of and
dependence on tobacco, alcohol and illicit substances require greater
attention by the public health community and appropriate policy responses
are needed to address these problems in different societies. Many gaps remain
to be filled in our understanding of the issues related to substance use and
dependence but this report shows that we already know a great deal about
the nature of these problems that can be used to shape policy responses.
This is an important report and I recommend it to a wide audience of health
care professionals, policy makers, scientists and students.
LEE Jong-wook
Director General
World Health Organization

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Opportunistic infections have always been accompaniments of medical conditions
that compromise host defenses. Because of the severe morbidity and mortality that
result from such infectious complications, these pose substantial challenges for the
clinician who cares for such individuals. With medical progress, the number of
immunocompromised patients is steadily climbing. Moreover the types of host
defense compromises are changing. As transplant practices evolve, as critical care
procedures advance, and as HIV management strategies change, the spectrum of
opportunistic pathogens shifts.
Initially, bacterial infections were most problematic. As strategies to control
bacterial infections improved, the herpesviruses came to increasing attention of clinicians.
Herpes simplex and varicella zoster virus cause considerable morbidity and
occasional mortality. Cytomegalovirus (CMV) became recognized as a major killer
of transplant recipients, but morbidity declined due to advances in rapid diagnostics
and the introduction of effective antiviral agents such as acyclovir and ganciclovir.
Today, the invasive fungal pathogens have seized center stage from the above
historically important opportunistic pathogens. During the 1980s the rate of nosocomial
invasive fungal disease in U.S. hospitals doubled with no sign of slowing during
the 1990s. Candida has become the fourth leading bloodstream isolate in U.S. hospitals,
surpassing many historically important bacterial pathogens. Estimates are
that the United States spends approximately one billion dollars annually for Candida
infections, and more than $650 million annually for Aspergillus disease. However,
accurate diagnostics and effective therapies have lagged for this emerging group of
opportunists. As survival from bacteria and the herpesviruses has improved, more
immunocompromised patients are now living to develop infection from fungi.
Candida is the most common genus of fungal pathogens. C. albicans long was
recognized as a cause of mucosal disease of the mouth, esophagus, and vagina in
patients with T-cell deficiency, as seen in patients with HIV infection, those treated
with corticosteroids or other potent immunosuppressive drugs, and patients with
lymphoreticular neoplasms. Fungemia is especially problematic in cancer patients
with chemotherapy-induced myelosuppression, blood and marrow transplant recipients,
and patients in critical care units on multiple antibiotics with venous, bladder,
or endotracheal catheters. With the increasing use of potent immunosuppressive
purine analogues, such as fludarabine, pentostatin, and cladribine, and anti-T and
anti-B cell antibodies (e.g., rituximab, alemtuzumab, and anti-thymocyte globulin)
in the management of hematolymphoreticular malignancies, increasing emphasis
on chemotherapy dose intensity in oncologic practice, and the growth in critical care,
the number of patients at risk for fungal diseases is growing.

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Keep wake-up times consistent and sleep quality will improve dramatically, giving you more energy and decreased sleep need.
Your body has an internal 24-hour clock which controls your circadian rhythm. Sleep quality is optimized during a very specific window of your circadian rhythm. If you learn to sleep exactly within that window you will enjoy the best sleep of your life. That is, you want to perfectly hit the “circadian low-point”, which is the time when your body is programmed to sleep.
If you sleep in on weekends your internal clock is always playing catch-up as it tries to match itself with your indecisive wake-up times. For each hour you sleep in late on weekends it will take an extra day during the week to reset your clock. Sleeping in on weekends makes it difficult to hit the circadian low point. Your body tries to increase sleep duration to compensate for poor sleep quality.
Keep wake-up times consistent. Even on weekends. Your sleep quality will skyrocket.
For those who don’t need alarm clocks (e.g. you are self-employed), you might be better off with free-running sleep…

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